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| Obesity Management In Leptin Resistance (LR) |
In that case, you can have a lot of fat making a lot of leptin, but it doesn’t work. The brain isn’t listening. No drop in appetite. No increased metabolism. Your brain might even think you’re starving, because as far as it’s concerned, there’s not enough leptin. So it makes you even hungrier.
Hormonal control of appetite and body fat :-
Leptin and ghrelin seem to be the big players in regulating appetite, which consequently influences body weight/fat. When we get hungrier, we tend to eat more. When we eat more, obviously, we maintain our body weight or gain that weight back.
Both leptin and ghrelin are peripheral signals with central effects. In other words, they’re secreted in other parts of the body (peripheral) but affect our brain (central).
Leptin is secreted primarily in fat cells, as well as the stomach, heart, placenta, and skeletal muscle. Leptin decreases hunger.
Ghrelin is secreted primarily in the lining of the stomach. Ghrelin increases hunger.
Both hormones respond to how well-fed you are; leptin usually also correlates to fat mass — the more fat you have, the more leptin you produce. Both hormones activate your hypothalamus (a part of your brain about the size of an almond).
What is Leptin?
First, it's important to understand that fat isn't simply just a storage tank for excess calories or "potential energy." Fat is actually an endocrine organ, like a thyroid or adrenal gland, for example. This means that fat – in this case white adipose tissue – secretes hormones, and leptin is one of them.
Leptin is a polypeptide hormone produced by adipocytes (fat cells). The more fat the adipocytes contain, the more leptin is released. Think of leptin as a metabolism controller and a hunger regulator. It links changes in body fat stores to CNS control of energy homeostasis
Factors that Contribute to Leptin Resistance:
As with all hormone issues, Leptin resistance is a complex issue with no singular cause, but there are many factors that can negatively impact Leptin
01. Fructose consumption(especially in forms like High Fructose Corn Syrup)
02. High stress levels
03. Consumption of a lot of simple carbs
04. Lack of sleep
05. High insulin levels (vicious cycle here)
06. Overeating
07. Exercising too much, especially if your hormones are already damaged
08. Grain and lectin consumption.
You eat above maintenance calories over a period of days or weeks :-
01. As you eat more, fat cells fill with triglyceride, which increases the release of the hormone leptin into the bloodstream.
02. The hypothalamus in your brain has an intricate system of communication with fat cells which include leptin receptors.
When leptin levels increase, leptin binds to leptin receptors in the hypothalamus, sending the message that you're "fueled up."
03. The hypothalamus then sends signals to the brain and the rest of the body, decreasing appetite and turning up your metabolic rate.
You eat below maintenance calories over a period of days or weeks :-
01. Your fat cells shrink as you diet, not eat, etc., and fat cells release less leptin.
02. Your brain senses that leptin levels are low, and that you are no longer "fueled up."
03. The hypothalamus senses the decrease in leptin levels, lowering metabolic rate and decreasing energy expenditure. It also sends a "hungry" signal, increasing appetite and encouraging you to eat.
Leptin action isn't confined to just the hypothalamus. There are leptin receptors all over the body. This allows leptin to precisely coordinate appetite, metabolism, and energy expenditure.
ACTION LEPTIN
01. Pancreatic islets -- (-) Insulin production and secretion.
02. Adipose tissue -- 01. (+) Fatty acid oxidation (7) 02. (+) Lipolysis (7) 03. (-) Lipogenesis
03. Liver--(+) Lipolysis (7) (-) Lipogenesis
04. Skeletal muscle --(+) Fatty acid oxidation.
Symptoms :-
The easiest way to do this if you are heavy is to look in the mirror. If you’re overweight you definitely are Leptin resistant.
If you still have a large appetite and crave carbohydrates, especially at night, these are also signs that you are likely Leptin resistant.
If you are fit or in decent shape and not sure based upon the above symptoms.
LAB DIAGONOSIS :-
01. Blood test and check your reverse T3. It will be elevated.
02. Salivary cortisol level.
03. With LR, you will always see higher cortisol levels later in the day.
04. Blood Fasting Leptin & Insulin.
MEDICAL TREATMENT :-
01. Byetta and Symlin (Aelopathy)
02. African plant, Irvingia Gabonensis (Herbal)
03. TRIKATU, SHILAJIT, TERMARIC + NEEM. (Ayurveda).
Leptin and Insulin : -
POTATO PHOTO
Leptin and insulin signaling have a very close relationship. When insulin increases, so does leptin. It makes sense – you eat a big meal, your insulin levels go up, and then leptin goes up, signaling to the brain that you're full and to keep the metabolism chugging. The insulin producing beta cells in the pancreas also have leptin receptors, where leptin is a negative regulator of insulin release. So there's a tight intertwined relationship between these two hormones.
01. You eat some wild salmon and a big sweet potato. The beta cells in your pancreas produce insulin in response to your blood glucose level.
02. Insulin stimulates leptin production in your fat cells.
03. Leptin levels go up, triggering the hypothalamus to decrease appetite.
04. High levels of leptin also tell your pancreas to stop making insulin.
But here's how it looks when you have leptin resistance :-
01. You eat some wild salmon and a big sweet potato with some pop tarts, as you're in "perma bulk" mode. The beta cells in your pancreas produce insulin in response to your blood glucose level.
02. Insulin stimulates leptin production in your fat cells, overwhelming your body.
03. Leptin levels go up but leptin resistance starts to set in.
04. High levels of leptin try to tell your pancreas to stop making insulin, but you're leptin resistant so the pancreas doesn't get the message to stop.
05. We now have chronically high levels of insulin, leading to insulin resistance.
Leptin and Your Thyroid :-
01. It's common knowledge among meat heads that when you diet, your thyroid slows down the conversion of T-4 to T-3. What isn't so commonly known is that leptin is a major player in keeping this conversion going.
02. When your brain senses correct levels of leptin, it tells your liver to convert the inactive T-4 to active T-3 (the active version of thyroid hormone). Your liver will stop this when your brain
perceives starvation, which is exactly what happens when you have leptin resistance.
Discussion and conclusion :-
This difference may reflect the different hormonal environments in men and women. For instance:-
01. Ghrelin seems to be affected by growth hormone release, which differs in men and women.
02. Leptin seems to influence reproduction and fertility in women, which is related to women’s body fat levels. Women appear to be much more sensitive than men to leptin levels… unless men are given estrogen.
03. Intranasally administered insulin makes men less hungry and lose weight, but makes women hungrier and gain weight… unless women’s estrogen levels, or men’s testosterone levels, are low.
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| AFTER TRANSFORMATION |
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