Saturday 30 July 2016

Weight Management During Uses Steroid, Medicine, Antibiotics




Weight Management During Uses Steroid, Medicine, Antibiotic
Weight Gain from Cancer Treatment with Steroids :-
A. Unfortunately, weight-gain from steroids is an issue that many cancer survivors experience. In general, the weight gain is due to a combination of factors, including fluid retention, increased calorie consumption, and decreased physical activity.
B. To lose weight safely, your friend can eat 500 fewer calories a day, burn 500 more calories per day, or a combination of both.

Here are the weight-loss tips we often give to our patients:- 
01. Decrease the amount of sodium in your diet by limiting the use of table salt and decreasing the amount of processed foods in your diet. Increase your consumption of potassium-rich foods (i.e. bananas, cantaloupe, kiwi, winter squash, avocado, etc.), to help prevent fluid retention.
02. To avoid gaining weight because of increased hunger:
a. Eat smaller meals more frequently (six small meals vs. three large meals).
b. Consume whole grains instead of refined carbohydrates.
c. nclude a serving of lean protein with all meals and snacks.
d. Eat fruits and vegetables. They are low in calories, but full of fiber and phytonutrients, both of     which may help prevent cancer while promoting weight management. Aim for 5-10 servings of colorful fruits and vegetables every day.

A. Keep a food journal (including the type of food, amount consumed, and method of preparation). This can help you track the total calories you've consumed each day.
B. To avoid hunger at night, eat meals consistently throughout the day, even if you are not ravenous.
C. Physical activity, such as walking, can help prevent weight gain and promote weight loss. We recommend you meet with your doctor to develop an activity plan that accommodates your lifestyle and medical condition.

Asthma Changing Your Appetite or Weight?
Poorly controlled asthma can affect your weight :-
01. When it comes to asthma and appetite, doctors and dietitians worry most about patients who eat too much, shun exercise for fear of becoming breathless, and end up being overweight.
02. But in a small minority of patients, poorly controlled asthma can leave them too breathless and fatigued to eat properly. Furthermore, a few asthma medications can cause upset stomachs or thrush infections in the mouth, leading to poor appetite.

The Link Between Asthma and Weight Gain :-
01. Parents of children with asthma often excuse them from physical activity if they complain of shortness of breath, she says. Although most asthma drugs, including inhaled steroids, typically don’t affect appetite, oral steroids can make some children eat more than double their usual amount, she says. 
02.   Many adult asthma patients who are on long-term oral steroids such as prednisone. A respiratory hospital and research center based in Denver, She has seen long-term use of these asthma drugs have dramatic effects on patients.
“03. Prednisone has a number of side effects that impact their nutritional status,”  “The biggest one is significant weight gain, partly due to an increase in appetite from the prednisone, partly due to the way the medication works and slows down the metabolism and leads to fluid retention.”
04.  “Weight loss in that population is no different than weight loss in any other population: balanced diet, increased activity, decreased calories -- basically, the same thing that everybody knows,” 

Asthma May Also Cause Poor Appetite :-
01. Although it’s much less common, some asthma patients have poor appetite.
02. Loss of appetite “is usually a signal that the asthma is not well controlled, not adequately treated,” If patients are not breathing well, their lungs can become hyper-inflated, she says. “They get full faster since their diaphragms under the lungs are pushing down on the stomach and it may not feel comfortable to their breathing to over-fill themselves.”

Asthma May Also Cause Poor Appetite continued. :-
Some patients with uncontrolled and under-treated asthma are so breathless that they have a hard time eating their meals. “The best thing to do for that is small, frequent meals,”  . “If it just takes that much energy to eat -- and for some people, it really does -- the best thing they can do is to eat smaller amounts throughout the day.”
Asthma can also leave some people too fatigued to cook . “They know the energy that it’s going to take them, not only to eat, but to prepare food. It almost ends up being a negative feedback mechanism, where they know how exhausted they’re going to be from thinking about getting out, preparing, cooking and then eating food. They don’t want to do it at all.”
Although long-term oral steroids can cause increased appetite and weight gain, asthma drugs can also cause stomach upset or mouth lesions, making eating more difficult. For example, higher doses of inhaled steroid doses to control asthma can cause fungal thrush infections in the mouth. But using a spacer or holding chamber with the inhaler can lessen the amount of medicine deposited in the mouth or throat, according to the Asthma and Allergy Foundation of America. Rinsing the mouth with water after each inhaler use also helps to prevent thrush.

Living With Asthma:  Better Nutrition :-
01. Take a multivitamin and calcium supplement daily. “If somebody is not eating properly or has that decreased appetite,”  supplementing with a multivitamin can provide nutrients. She also recommends a calcium supplement, especially for people on long-term, high doses of oral steroids, because those drugs can decrease calcium absorption and lead to bone loss.
02. Breathe evenly while you are chewing and eating. Try to relax during meals and stop eating if you need to catch your breath.
03. Double or triple your favorite recipes and freeze the extra portions. Turn to these homemade frozen entrees when you don’t feel like cooking.   
04.  Use prepared foods to save time and energy in the kitchen. Frozen meals, prepared foods or take-out meals can make your life easier. But don’t overdo it. The sugar, salt or fat in these foods may be higher than in homemade meals.
05. For tasks that require the most effort, do them when you have the most energy. Grocery shopping can be tiring if you have asthma, so do it when you feel the freshest, for example, in the morning or after a rest. Or enlist a friend or family member to buy your groceries.
06. Don't stand in the kitchen when you can sit. Keep a barstool by the kitchen counter, or do your chopping, cutting and mixing at the kitchen tabl 

FOOD CRAVING MANAGEMENT :- 

What is a food craving?
A classic craving is an urge or a strong desire for a particular food," she says. "It’s much more than just comfort eating.
"Food most likely [to be] craved is high energy, high calorie, and high fat food. They are treat foods that are usually restricted.
"People don’t crave broccoli and cabbage. It’s more likely to be sweets or chocolates."
A craving is not hunger. The desire doesn’t come from your stomach but from your brain- which is much more complex.


Cravings come from the brain not the belly :-
There are two reasons why people have food cravings. They need a shot of energy or they are miserable.
"As far as energy is concerned, people crave high calorie foods, high in carbohydrate, fat and sugar because it gives them a fast burst of energy. Even though it would be much better for them to have a foodstuff with a better nutritional value without empty calories." Liz says the second reason for craving food is because it makes us happy. "We have a primitive response, as humans, we live to experience pleasure, through Sex and relationships and also through Eating and drinking." "If you are miserable or in crisis in one area of your life, you aren’t getting pleasure from it and turn to food to give you that happiness kick. "If you find no pleasure in life - you can get a chemical fix from food."


Don't blame nutrition ;-
01. One popular myth is that people crave certain foods to fill a nutritional deficiency. "My body’s telling me I need that family sized bag of crisps as I’m lacking salt!" isn’t a good enough excuse, I’m afraid. "It’s very rare that people in the UK have deficiencies that lead to cravings," according to Professor Hetherington. "Most cravings are categorised in terms of pleasure and reward." Vegetarians will occasionally fall off the wagon and have a burger or a bacon sandwich, blaming their own body’s need for meat. Good excuse to blame your body but it’s actually your brain that wants the meat.
02. She says in one experiment when young people were kept on a liquid diet with all of the correct nutrients, they craved food with texture like steak and pasta, food that had substance to it. So it may be the feel of it in your mouth that adds to the craving. Dietitian Gaynor Bussell speaks for the British Dietetic Association: "You have cravings for all sorts of psychological reasons, there has been some work looking at a possible physiological need which leads to cravings but that’s never been proven". She says if you have a certain medical condition like Type 2 diabetes or polycystic ovary syndrome (PCOS), your body may occasionally crave carbs and sugar.


Healthy eating health centre. Taking control of your food cravings :-
The gender divide:-
01. Culture and gender play a big role in cravings. In his research, men were more likely to crave pizza, pasta, and soup over cakes and biscuits. Why? Besides being tasty and filling, such hot, savoury foods reminded them of attention from their mothers or wives.
02. In contrast, women like these foods too but associated them with work, including preparation and cleaning up. So instead, women tended to crave hassle-free snack foods, like chocolate, biscuits and ice cream.
03. Good mood, bad mood
Certain emotions, including stress, sadness and boredom, can promote cravings.
A bad mood can become a conditioned cue for eating. It you’ve had hassle from the kids, a hard day at work or a row with your husband, that’s often a cue to go to the fridge and eat something.
Food is always there for you - it won’t cheat on you, it won’t disagree with you and it doesn’t answer back!
Those negative moods get all the press, but Professor Wansink suggests happy moods might be even more likely to cause cravings. In his survey of about 1,000 people, 86% reported they craved comfort foods when they were happy and 74% had cravings when they wanted to celebrate or reward themselves. In contrast, 52% had cravings when they were bored and 39% when they were sad or lonely.


So you want to control your cravings. What should you do?
A. Be prepared: Keep your fruit bowl well stocked and always have healthy snacks in the fridge, like carrot sticks and grapes. So if you feel your craving creeping up, just grab a banana and a big glass of water or maybe even have a teaspoon of honey or a handful of raisins to satisfy your need for sweet stuff.
B. In real life that might not work! But it’s worth a try.
C. Do something unrelated to food. The mantra "pizza, pizza, pizza" is playing inside your head, you’ve got the home delivery menu in one hand and the phone in the other. What do you do? Yes, that’s right, have a bath! Run yourself a really deep, hot bath with lots of bubbles, play relaxing music, light a few candles and indulge yourself.
D. Do something else that gives you pleasure. As our experts say we have cravings because they give us pleasure so do something else that does that. Why not go for a run which will release feel-good hormones and burn calories?


Cut down or avoid temptation :-
a. Just have a small square of chocolate rather than a whole bar. This is easier said than done. You need a serious amount of willpower for that.
b. Don’t watch TV shows about food or adverts for food (which is difficult  - so consider getting rid of your TV, renting a film or recording your favourite shows and winding through any ads!)
c.That may be a bit extreme as Dr. Atin banerjee says. "The presence of food itself is more powerful than an image of food in triggering cravings." 
d.So maybe just don’t keep sweet foods in your house if you know you crave them. 
e.If you don’t live alone, why not get someone in your house such as your husband, child or flatmate to hide all of the biscuits, cakes, chocolates and crisps so you won’t know where they are. 
f. Dietitian Dr. Atin banerjee suggests keeping a food diary. "Write down what you ate, whether you were actually hungry when you had it and watch for the triggers so that you can make behavioural changes and be more mindful in your eating."

Regular cravings
01. When you get into the habit of having a treat food at a certain time, every day, it may be tough to stop.
02. Dr. Atin Banerjee says: "If at say 3 o’clock every afternoon you have a chocolate bar, your body will learn to expect it and crave it.
03."The most dangerous cravings are the ones that are chronic. Those are going to be the most difficult ones to deal with.
04. It's better to have a foolproof plan. Make sure to have chewing gum in your hand, ready to pop into your mouth when the craving strikes.


Weight Loss: Emotional Eating:- 
A. Emotional eating is the practice of consuming large quantities of food -- usually "comfort" or junk foods -- in response to feelings instead of hunger. Experts estimate that 75% of overeating is caused by emotions.
B. Depression, boredom, loneliness, chronic anger, anxiety, frustration, stress, problems with interpersonal relationships and poor self-esteem can result in overeating and unwanted weight gain.
C. By identifying what triggers our emotional eating, we can substitute more appropriate techniques to manage our emotional problems and take food and weight gain out of the equation.

How to Identify Eating Triggers ;- (Situations and emotions that trigger us to eat fall into five main categories).
01. Social. Eating when around other people. For example, excessive eating can result from being encouraged by others to eat; eating to fit in; arguing; or feelings of inadequacy around other people.
02. Emotional. Eating in response to boredom, stress, fatigue, tension, depression, anger, anxiety, or loneliness as a way to "fill the void."
03. Situational. Eating because the opportunity is there. For example, at a restaurant, seeing an advertisement for a particular food, passing by a bakery. Eating may also be associated with certain activities such as watching TV, going to the movies or a sporting event, etc.
04. Thoughts. Eating as a result of negative self-worth or making excuses for eating. For example, scolding oneself for looks or a lack of will power.
05. Physiological. Eating in response to physical cues. For example, increased hunger due to skipping meals or eating to cure headaches or other pain.


How to Stop Emotional Eating :-
A. Identifying emotional eating triggers and bad eating habits is the first step; however, this alone is not sufficient to alter eating behavior. Usually, by the time you have identified a pattern, eating in response to emotions or certain situations has become a habit. Now you have to break that habit.
B. Developing alternatives to eating is the second step. When you start to reach for food in response to an eating trigger, try one of the following activities instead. 

01. Read a good book or magazine or listen to music.
02. Go for a walk or jog.
03. Take a bubble bath.
04. Do deep breathing exercises.
05. Play cards or a board game.
06. Talk to a friend.
07. Do housework, laundry, or yard work.
08. Wash the car.
09. Write a letter.
10. Or do any other pleasurable or necessary activity until the urge to eat passes.
11. Relaxation exercises
12. Meditation
13. Individual or group counseling

Hypertension (HTN) & Obesity Management

High blood pressure is a common condition in which the force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease. 
Blood pressure is determined by the amount of blood your heart pumps and the amount of resistance to blood flow in your arteries. The more blood your heart pumps and the narrower your arteries, the higher your blood pressure. 

Causes :-
There are two types of high blood pressure :-
01. Primary (essential) hypertension For most adults, there's no identifiable cause of high blood pressure. This type of high blood pressure, called essential hypertension or primary hypertension, tends to develop gradually over many years. 
02. Secondary hypertension Some people have high blood pressure caused by an underlying condition. This type of high blood pressure, called secondary hypertension, tends to appear suddenly and cause higher blood pressure than does primary hypertension. Various conditions and medications can lead to secondary hypertension, including: 
03. Kidney problems
04. Adrenal gland tumors
05. Certain defects in blood vessels you're born with (congenital)
06. Certain medications, such as birth control pills, cold remedies, decongestants, over-the-counter pain relievers and some prescription drugs
07. Illegal drugs, such as cocaine and amphetamines.

Symptoms :-
A. Most people with high blood pressure have no signs or symptoms, even if blood pressure readings reach dangerously high levels. 
B. Although a few people with early-stage high blood pressure may have dull headaches, dizzy spells or a few more nosebleeds than normal, these signs and symptoms typically don't occur until high blood pressure has reached a severe — even life-threatening — stage. 


Risk factors :-  (High blood pressure has many risk factors, including: )

01. Age. The risk of high blood pressure increases as you age. Through early middle age, high blood pressure is more common in men. Women are more likely to develop high blood pressure after menopause.
02.  Race. High blood pressure is particularly common among blacks, often developing at an earlier age than it does in whites. Serious complications, such as stroke and heart attack, also are more common in blacks. 
03. Family history. High blood pressure tends to run in families. 
04. Being overweight or obese. The more you weigh, the more blood you need to supply oxygen and nutrients to your tissues. As the volume of blood circulated through your blood vessels increases, so does the pressure on your artery walls.
05. Not being physically active. People who are inactive tend to have higher heart rates. The higher your heart rate, the harder your heart must work with each contraction — and the stronger the force on your arteries. Lack of physical activity also increases the risk of being overweight. 
6. Using tobacco. Not only does smoking or chewing tobacco immediately raise your blood pressure temporarily, but the chemicals in tobacco can damage the lining of your artery walls. This can cause your arteries to narrow, increasing your blood pressure. Secondhand smoke also can increase your blood pressure. 
7. Too much salt (sodium) in your diet. Too much sodium in your diet can cause your body to retain fluid, which increases blood pressure. 
8. Too little potassium in your diet. Potassium helps balance the amount of sodium in your cells. If you don't get enough potassium in your diet or retain enough potassium, you may accumulate too much sodium in your blood. 
Too little vitamin D in your diet. It's uncertain if having too little vitamin D in your diet can lead to high blood pressure. Vitamin D may affect an enzyme produced by your kidneys that affects your blood pressure. 
10. Drinking too much alcohol. Over time, heavy drinking can damage your heart. Having more than two drinks a day can raise your blood pressure. 
11. Stress. High levels of stress can lead to a temporary, but dramatic, increase in blood pressure. If you try to relax by eating more, using tobacco or drinking alcohol, you may only increase problems with high blood pressure. 
12. Certain chronic conditions. Certain chronic conditions also may increase your risk of high blood pressure, including high cholesterol, diabetes, kidney disease and sleep apnea.
Sometimes pregnancy contributes to high blood pressure, as well. 
Although high blood pressure is most common in adults, children may be at risk, too. For some children, high blood pressure is caused by problems with the kidneys or heart. But for a growing number of kids, poor lifestyle habits — such as an unhealthy diet and lack of exercise — contribute to high blood pressure. 

Complications :- 
The excessive pressure on your artery walls caused by high blood pressure can damage your blood vessels, as well as organs in your body. The higher your blood pressure and the longer it goes uncontrolled, the greater the damage. 


Uncontrolled high blood pressure can lead to: 
A. Heart attack or stroke. High blood pressure can cause hardening and thickening of the arteries (atherosclerosis), which can lead to a heart attack, stroke or other complications.
B. Aneurysm. Increased blood pressure can cause your blood vessels to weaken and bulge, forming an aneurysm. If an aneurysm ruptures, it can be life-threatening.
C. Heart failure. To pump blood against the higher pressure in your vessels, your heart muscle thickens. Eventually, the thickened muscle may have a hard time pumping enough blood to meet your body's needs, which can lead to heart failure.
D. Weakened and narrowed blood vessels in your kidneys. This can prevent these organs from functioning normally. 
E.. Thickened, narrowed or torn blood vessels in the eyes. This can result in vision loss. 
F. Metabolic syndrome. This syndrome is a cluster of disorders of your body's metabolism — including increased waist circumference, high triglycerides, low high-density lipoprotein (HDL), or "good," cholesterol, high blood pressure, and high insulin levels. If you have high blood pressure, you're more likely to have other components of metabolic syndrome. The more components you have, the greater your risk of developing diabetes, heart disease or stroke. 
G. Trouble with memory or understanding. Uncontrolled high blood pressure may also affect your ability to think, remember and learn. Trouble with memory or understanding concepts is more common in people who have high blood pressure.

Tests and diagnosis :-
Blood pressure is measured with an inflatable arm cuff and a pressure-measuring gauge. A blood pressure reading, given in millimeters of mercury (mm Hg), has two numbers. The first, or upper, number measures the pressure in your arteries when your heart beats (systolic pressure). The second, or lower, number measures the pressure in your arteries between beats (diastolic pressure).

Blood pressure measurements fall into four general categories
01. Normal blood pressure. Your blood pressure is normal if it's below 120/80 mm Hg. However, some doctors recommend 115/75 mm Hg as a better goal. Once blood pressure rises above 115/75 mm Hg, the risk of cardiovascular disease begins to increase.
02.  Prehypertension. Prehypertension is a systolic pressure ranging from 120 to 139 mm Hg or a diastolic pressure ranging from 80 to 89 mm Hg. Prehypertension tends to get worse over time. 

Stage 1 hypertension. Stage 1 hypertension is a systolic pressure ranging from 140 to 159 mm Hg or a diastolic pressure ranging from 90 to 99 mm Hg.
Stage 2 hypertension. More severe hypertension, stage 2 hypertension is a systolic pressure of 160 mm Hg or higher or a diastolic pressure of 100 mm Hg or higher.
Both numbers in a blood pressure reading are important. But after age 50, the systolic reading is even more significant. Isolated systolic hypertension — when diastolic pressure is normal but systolic pressure is high — is the most common type of high blood pressure among people older than 50. 

Medications to treat high blood pressure ;-
01. Thiazide diuretics. Diuretics, sometimes called water pills, are medications that act on your kidneys to help your body eliminate sodium and water, reducing blood volume. Thiazide diuretics are often the first — but not the only — choice in high blood pressure medications. If you're not taking a diuretic and your blood pressure remains high, talk to your doctor about adding one or replacing a drug you currently take with a diuretic. 
02. Beta blockers. These medications reduce the workload on your heart and open your blood vessels, causing your heart to beat slower and with less force. When prescribed alone, beta blockers don't work as well in blacks or in older adults — but they're effective when combined with a thiazide diuretic.
03. Angiotensin-converting enzyme (ACE) inhibitors. These medications help relax blood vessels by blocking the formation of a natural chemical that narrows blood vessels.
04. Angiotensin II receptor blockers (ARBs). These medications help relax blood vessels by blocking the action — not the formation — of a natural chemical that narrows blood vessels.
05. Calcium channel blockers. These medications help relax the muscles of your blood vessels. Some slow your heart rate. Calcium channel blockers may work better for blacks and older adults than do ACE inhibitors or beta blockers alone. A word of caution for grapefruit lovers, though. Grapefruit juice interacts with some calcium channel blockers, increasing blood levels of the medication and putting you at higher risk of side effects. Talk to your doctor or pharmacist if you're concerned about interactions. 
06. Renin inhibitors. Aliskiren (Tekturna) slows down the production of renin, an enzyme produced by your kidneys that starts a chain of chemical steps that increases blood pressure. Tekturna works by reducing the ability of renin to begin this process. Due to a risk of serious complications, including stroke, you shouldn't take aliskiren with ACE inhibitors or ARBs.


If you're having trouble reaching your blood pressure goal with combinations of the above medications, your doctor may prescribe: -
A. Alpha blockers. These medications reduce nerve impulses to blood vessels, reducing the effects of natural chemicals that narrow blood vessels.
B. Alpha-beta blockers. In addition to reducing nerve impulses to blood vessels, alpha-beta blockers slow the heartbeat to reduce the amount of blood that must be pumped through the vessels.
C. Central-acting agents. These medications prevent your brain from signaling your nervous system to increase your heart rate and narrow your blood vessels.
D. Vasodilators. These medications work directly on the muscles in the walls of your arteries, preventing the muscles from tightening and your arteries from narrowing.


Lifestyle changes to treat high blood pressure. No matter what medications your doctor prescribes to treat your high blood pressure, you'll need to make lifestyle changes to lower your blood pressure. These changes usually include eating a healthier diet with less salt (the Dietary Approaches to Stop Hypertension, or DASH, diet), exercising more, quitting smoking and losing weight. 

Lifestyle and home remedies:-
1. Eat healthy foods. 
2. Decrease the salt in your diet 
3. Maintain a healthy weight 
4. Increase physical activity. 
5. Limit alcohol 
6. Don't smoke 
7. Manage stress 
8. Monitor your blood pressure at home. 
9. Practice relaxation or slow, deep breathing. 

Alternative medicine :- 
Although diet and exercise are the best tactics to lower your blood pressure, some supplements also may help decrease it. These include 
01. Alpha-linolenic acid
02. Blond psyllium
03. Calcium
04. Cocoa
05. Cod-liver oil
06. Coenzyme Q10
07. Omega-3 fatty acids
08. Garlic.

Tips to help you remember to take your blood pressure medicine :-

01. Take your medicine after you brush your teeth. Keep it with your toothpaste as a reminder.
02. Put self-stick notes in visible places to remind yourself.
03. Use a weekly pillbox to store your medicines so you can see at a glance whether you’ve taken the current day’s dose.
04. Keep your medicine on the nightstand next to your bed to remind yourself to take your evening medications.
05. Ask a friend or relative to call your telephone answering machine to remind you to take your medicine; then don’t erase the message.
06. Establish a buddy system with a friend who also takes a medication each day.

AFTER TRANSFORMATION

Obesity Management Hyperlipidemia (Cholesterol, TGL, LDL,HDL, VDRL)



Obesity Management Hyperlipidemia (Cholesterol, TGL, LDL,HDL, VDRL)
Description ;-
Hyperlipidemia is a heterogeneous group of disorders characterized by an excess of lipids in the bloodstream. These lipids include cholesterol, cholesterol esters, phospholipids, and triglycerides. Lipids are transported in the blood as large 'lipoproteins'

Lipoproteins are divided into four major classes, based on density :-
a. Very low-density lipoproteins (VLDL).
b. Intermediate-density lipoproteins (IDL).
c. Low-density lipoproteins (LDL).
d. High-density lipoproteins (HDL).

MANAGEMENT :-
01. Drug therapy.
02. Lifestyle Modification.
03. Behavioral modification. 
04. Nutritional Treatment.
05. Exercise Therapy.
06. Herbal Therapy.

KNOW MORE :- 

01. Primary hyperlipidemias are probably genetically based, but the genetic defects are known for only a minority of patients.
02. Secondary hyperlipidemia may result from diseases such as diabetes, thyroid disease, renal disorders, liver disorders, and Cushing's syndrome, as well as obesity, alcohol consumption, estrogen administration, and other drug-associated changes in lipid metabolism.
03. Hyperlipidemia is a major, modifiable risk factor for atherosclerosis and cardiovascular disease, including coronary heart disease; this is true both of disorders involving hypercholesterolemia and hypertriglyceridemia.


Synonyms :-
01. Hypercholesterolemia
02. Hypertriglyceridemia
03. Hyperlipoproteinemia
04. Dyslipidemia
05. High serum cholesterol

Key points :-
A. CHypercholesterolemia, regardless of cause, is a major modifiable risk factor for coronary artery disease
B. Hyperlipidemia is usually asymptomatic until serum lipid levels are severely elevated, and well beyond the range at which cardiovascular morbidity and mortality are increased
C. Identification of patients who would benefit from lipid-lowering therapy, therefore, depends on screening of adults and certain children for high serum lipid levels, as well as obtaining a careful history to detect risk factors that suggest the patient would benefit from lipid-lowering therapy, even if serum lipid levels are 'normal'
D. Effective and well-tolerated therapy for lowering LDL cholesterol (LDL-C) is now available, and should receive widespread application
E. Epidemiologic studies predict that for each 1% reduction in the level of LDL-C, there is a 1% to 1.5% reduction in the risk of major cardiovascular events
F. Treatment goals for lipid-lowering therapy depend on risk stratification of the patient to identify appropriate lipid level 'targets'
G. Lifestyle modifications, such as weight loss, exercise, and dietary changes, are also key in long-term management.

Hypertriglyceridemia :-
01. Drug therapy for elevated triglycerides is presently available, and new drugs are being developed.
02. Contrary to widespread belief, hypertriglyceridemia is also a modifiable risk factor for cardiovascular disease.

Cardinal features ;-
a. Hyperlipidemia is a group of disorders characterized by an excess of serum cholesterol, especially excess LDL-C and/or excess triglycerides
b. Hypercholesterolemia is generally asymptomatic
c. Hypertriglyceridemia is generally asymptomatic until triglyceride levels are sustained above 1000 mg/dL - symptoms then include dermatologic manifestations, such as eruptive xanthomas, and gastrointestinal manifestations, such as pancreatitis
d. Hyperlipidemias are most often genetically determined, but can be caused or amplified by abnormal diet, drugs, and certain disease conditions.
e. Drugs associated with hyperlipidemias include immunosuppressive therapy, thiazide diuretics, progestin's, retinoid, anabolic steroids, glucocorticoids, HIV protease inhibitors, alcohol, retinoic acid, and beta-blockers
f. Diseases associated with secondary hyperlipidemias include diabetes mellitus (type I and type II), hypothyroidism, Cushing's syndrome, chronic kidney disease, nephritic syndrome, and cholestatic disorders
g. Hyperlipidemia is a major modifiable risk factor for atherosclerosis and cardiovascular disease, including coronary heart disease
h. Treatment goals are based on absolute serum levels of lipids, and/or risk stratification of patients - more aggressive treatment to achieve lower lipid target levels is indicated in higher-risk patients
i. Evidence shows that effective therapy to lower serum LDL-C is associated with dramatic benefits in terms of short-term morbidity and mortality in patients with coronary artery disease, and long-term morbidity and mortality even in low-risk patients

A. Common causes :-Familial combined hypercholesterolemia is the most common primary lipid disorder, characterized by moderate elevation of plasma triglycerides and cholesterol and reduced plasma HDL-C
B. Familial hypertriglyceridemia.

Rare causes :-
Hypercholesterolemia :-

01. Familial hypercholesterolemia with raised cholesterol
02. Familial dysbetalipoproteinemia (Type III hyperlipoproteinemia)
03 Familial defective apolipoprotein (Apo) B100
04. Apo AI deficiency
05. Autosomal recessive hypercholesterolemia
06. Tangier disease
07. Wolman disease
08. Sitosterolemia
09. Remnant hyperlipoproteinemia with marked combined hyperlipidemia
10. Polygenic hypercholesterolemia
11. Lecithin:cholesterol acyltransferase deficiency.

Hypertriglyceridemia :-
Lipoprotein lipase deficiency (familial chylomicronemia syndrome, type I hyperlipoproteinemia) with extremely raised triglycerides and moderately raised cholesterol. 

Serious causes ;-
A. Homozygous familial hypercholesterolemia.
B. Contributory or predisposing factors
C. Other diseases that may contribute to hyperlipidemia include:
D. Insulin-dependent diabetes mellitus
E. Non-insulin dependent diabetes mellitus
F. Hypothyroidism
G. Cushing's syndrome
H. Renal failure and nephrotic syndrome
I. Cholestatic disorders
J. Dysproteinemias.

Drugs associated with hyperlipidemia include :-
01. Anabolic steroids
02. Retinoids
03. Birth control pills and estrogens
04. Corticosteroids
05. Thiazide diuretics
06. Protease inhibitors
07. Beta-blockers.

Dietary causes include :-
A. Fat intake per total calories greater than 40%
B. Saturated fat intake per total calories greater than 10%
C. Cholesterol intake greater than 300 mg per day
D. Habitual excessive alcohol use.

Lifestyle contributing factors include :-
01. Habitual excessive alcohol use
02. Obesity
03. Lack of exercise.

Always Co-ordinate with Respective Cardiologist/ Clinical Nutritionist / Medical Professional.

AFTER TRANSFORMATION




Obesity Management Hypercortisolism (Cushing's syndrome)



Obesity Management Hypercortisolism (Cushing's syndrome)



Cushing's syndrome describes the signs and symptoms associated with prolonged exposure to inappropriately high levels of the hormone cortisol. This can be caused by taking glucocorticoid drugs, or diseases that result in excess cortiso, adrenocorticotropi hormone (ACTH, or CRH levels.

Cushing's disease refers to a pituitary-dependent cause of Cushing's syndrome: a tumor (adenoma) in the pituitary gland produces large amounts of ACTH, causing the adrenal glands to produce elevated levels of cortisol. It is the most common non-iatrogenic cause of Cushing's syndrome, responsible for 70% of cases excluding glucocorticoid related cases. An easy way to distinguish Cushing's syndrome from Cushing's disease is that the measured ACTH levels are lower in the former. The decrease in ACTH is due to increased negative feedback of cortisol on the hypothalamus and anterior pituitary.

-:In summary:-
01. Rapid weight gain
02. Moodiness, irritability, or depression
03. Muscle and bone weakness
04. Memory and attention dysfunction
05. Osteoporosis
06. Diabetes mellitus
07. Hypertension
08. Immune suppression
09. Sleep disturbances
10. Menstrual disorders such as amenorrhea in women and decreased fertility in men
11. Hirsutism
12. Hair loss.
13. Hypercholesterolemia.


Signs and symptoms :-
01. Symptoms include rapid weight gain, particularly of the trunk and face with sparing of the limbs (central obesity). Common signs include the growth of fat pads along the collarbone, on the back of the neck or "buffalo hump" and on the face "moon facies". Other symptoms include hyperhidrosis(excess sweating), telangiectasia (dilation of capillaries), thinning of the skin (which causes easy bruising and dryness, particularly the hands) and other mucous membranes, purple or red striae (the weight gain in Cushing's syndrome stretches the skin, which is thin and weakened, causing it to hemorrhage) on the trunk, buttocks, arms, legs or breasts, proximal muscle weakness (hips, shoulders), and hirsutism (facial male-pattern hair growth), baldness and/or extremely dry and brittle hair. In rare cases, Cushing's can cause hypocalcaemia. The excess cortisol may also affect other endocrine systems and cause, for example, insomnia, inhibited aromatase, reduced libido, impotence in men, amenorrhoea/oligomenorrhe  and infertility in women due to elevations in androgens. Studies have also shown that the resultant amenorrhea is due to hypercortisolism, which feeds back onto the hypothalamus resulting in decreased levels of GnRH release.

02. Cognitive conditions, including memory and attention dysfunctions, as well as depression are commonly associated with elevated cortisol and may be early indicators of exogenous or endogenous Cushing's. Patients frequently suffer various psychological disturbances, ranging from euphoria to psychosis. Depression and anxiety are also common. Other striking and distressing skin changes that may appear in Cushing's syndrome include facial acne, susceptibility to superficial dermatophyte and malassezia infections, and the characteristic purplish, atrophic striae on the abdomen

03. Other signs include polyuria (and accompanying polydipsia), persistent hypertension (due to cortisol's enhancement of epinephrine’s vasoconstrictive effect) and insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugar) and insulin resistance which can lead to diabetes mellitus. Insulin resistance is accompanied by skin changes such as acanthosis nigricans in the axilla and around the neck, as well as skin tags in the axilla. Untreated Cushing's syndrome can lead to heart disease and increased mortality. Cortisol can also exhibit mineralcorticoid activity in high concentrations, worsening the hypertension and leading to hypokalemia (common in ectopic ACTH secretion). Furthermore, excessive cortisol may lead to gastrointestinal disturbances, opportunistic infections and impaired wound healing related to cortisol's suppression of the immune and inflammatory responses. Osteoporosis is also an issue in Cushing's syndrome since osteoblast activity is inhibited. Additionally, Cushing's syndrome may cause sore and aching joints, particularly in the hip, shoulders, and lower back.

04. Cushing’s syndrome includes all the causes of increased cortisol leading to the diseased state. Cushing’s disease is a specific type of Cushing’s syndrome caused by a pituitary tumor leading to excessive production of ACTH (Adrenocorticotropic hormone). Excessive ACTH stimulates the adrenal cortex to produce high levels of cortisol, producing the disease state. Cushing's disease due to excess ACTH may also result in hyperpigmentation. This is due to Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from Pro-opiomelanocortin (POMC). A variant of Cushing's disease can be caused by ectopic, i.e. extra-pituitary, ACTH production from for example a small cell lung cancer. When Cushing's syndrome is caused by an increase of cortisol at the level of the adrenal glands (via an adenoma or hyperplasia), negative feedback ultimately reduces ACTH production in the pituitary. In these cases, ACTH levels remain low and no hyperpigmentation develops. While all Cushing’s disease is Cushing’s syndrome, not all Cushing’s syndrome is Cushing’s disease.

Causes Exogenous vs. endogenous:- 
The most common cause of Cushing's syndrome is exogenous  administration of glucocorticoids prescribed by a health care practitioner to treat other diseases (called iatrogenic Cushing's syndrome). This can be an effect of corticosteroid treatment of a variety of disorders such as asthma and rheumatoid arthritis  or in immunosuppression after an organ transplant. Administration of synthetic ACTH is also possible, but ACTH is less often prescribed due to cost and lesser utility. Although rare, Cushing's syndrome can also be due to the use of medroxyprogesterone. In this form of Cushing's, the adrenal glands atrophy due to lack of stimulation by ACTH, since glucocorticoids downregulate production of ACTH. Cushing syndrome in childhood usually results from use of glucocorticoid medication

Pseudo-Cushing's syndrome :-
Elevated levels of total cortisol can also be due to estrogen found in oral contraceptive pills that contain a mixture of estrogen and progesterone, leading to Pseudo-Cushing's syndrome. Estrogen can cause an increase of cortisol-binding globulin and thereby cause the total cortisol level to be elevated. However, the total free cortisol, which is the active hormone in the body, as measured by a 24 hour urine collection for urinary free cortisol, is normal

Diagnosis:- 
When Cushing's syndrome is suspected, either a dexamethasone suppression test (administration of dexamethasone and frequent determination of cortisol and ACTH level), or a 24-hour urinary measurement for cortisol offer equal detection rates. Dexamethasone is a glucocorticoid and simulates the effects of cortisol, including negative feedback on the pituitary gland. When dexamethasone is administered and a blood sample is tested, cortisol levels >50nmol/L (1.81 µg/dL) would be indicative of Cushing's syndrome because there is an ectopic source of cortisol or ACTH (such as adrenal adenoma) that is not inhibited by the dexamethasone. A novel approach, recently cleared by the US FDA, is sampling cortisol in saliva over 24 hours, which may be equally sensitive, as late night levels of salivary cortisol are high in Cushingoid patients. Other pituitary hormone levels may need to be ascertained. Performing a physical examination to determine any visual field defect may be necessary if a pituitary lesion is suspected, which may compress the optic chiasm causing typical bitemporal hemianopia.

Cushing’s Syndrome :- 
C - Central obesity, Clavical fat pads, Collagen fiber weakness, Comedones (acne).
U - Urinary free cortisol and glucose increase.
S - Striae, Suppressed immunity.
H - Hypercortisolism, Hypertension, Hyperglycemia, Hypercholesterolemia, Hirsutism, Hypernatremia, Hypokalemia.
I - Iatrogenic (Increased administration of corticosteroids).
N - Noniatrogenic (Neoplasms).
G - Glucose intolerance, Growth retardation.

Treatments ;-
Pl Referred to client immediately to  Respected Endocrinologist & Touch with Dr. Always.


Obesity Management In Leptin Resistance (LR)


Obesity Management  In Leptin Resistance (LR)
DEFINATION :-
In that case, you can have a lot of fat making a lot of leptin, but it doesn’t work. The brain isn’t listening. No drop in appetite. No increased metabolism. Your brain might even think  you’re starving, because as far as it’s concerned, there’s not enough leptin. So it makes you even hungrier.

Hormonal control of appetite and body fat :-
Leptin and ghrelin seem to be the big players in regulating appetite, which consequently influences body weight/fat. When we get hungrier, we tend to eat more. When we eat more, obviously, we maintain our body weight or gain that weight back.
Both leptin and ghrelin are peripheral signals with central effects. In other words, they’re secreted in other parts of the body (peripheral) but affect our brain (central).
Leptin is secreted primarily in fat cells, as well as the stomach, heart, placenta, and skeletal muscle. Leptin decreases hunger.

Ghrelin is secreted primarily in the lining of the stomach. Ghrelin increases hunger.
Both hormones respond to how well-fed you are; leptin usually also correlates to fat mass — the more fat you have, the more leptin you produce. Both hormones activate your hypothalamus (a part of your brain about the size of an almond).

What is Leptin?
First, it's important to understand that fat isn't simply just a storage tank for excess calories or "potential energy." Fat is actually an endocrine organ, like a thyroid or adrenal gland, for example. This means that fat – in this case white adipose tissue – secretes hormones, and leptin is one of them.
Leptin is a polypeptide hormone produced by adipocytes (fat cells). The more fat the adipocytes contain, the more leptin is released. Think of leptin as a metabolism controller and a hunger regulator. It links changes in body fat stores to CNS control of energy homeostasis 

Factors that Contribute to Leptin Resistance: 
As with all hormone issues, Leptin resistance is a complex issue with no singular cause, but there are many factors that can negatively impact Leptin

01. Fructose consumption(especially in forms like High Fructose Corn Syrup)
02. High stress levels
03. Consumption of a lot of simple carbs
04. Lack of sleep
05. High insulin levels (vicious cycle here)
06. Overeating
07. Exercising too much, especially if your hormones are already damaged
08. Grain and lectin consumption.

You eat above maintenance calories over a period of days or weeks :-
01. As you eat more, fat cells fill with triglyceride, which increases the release of the hormone leptin into the bloodstream.
02. The hypothalamus in your brain has an intricate system of communication with fat cells which include leptin receptors. 
When leptin levels increase, leptin binds to leptin receptors in the hypothalamus, sending the message that you're "fueled up."
03. The hypothalamus then sends signals to the brain and the rest of the body, decreasing appetite and turning up your metabolic rate.

You eat below maintenance calories over a period of days or weeks :-
01. Your fat cells shrink as you diet, not eat, etc., and fat cells release less leptin.
02. Your brain senses that leptin levels are low, and that you are no longer "fueled up."
03. The hypothalamus senses the decrease in leptin levels, lowering metabolic rate and decreasing energy expenditure. It also sends a "hungry" signal, increasing appetite and encouraging you to eat.


Leptin action isn't confined to just the hypothalamus. There are leptin receptors all over the body. This allows leptin to precisely coordinate appetite, metabolism, and energy expenditure.
ACTION LEPTIN
01. Pancreatic islets --     (-) Insulin production and secretion.
02. Adipose tissue --   01.   (+) Fatty acid oxidation (7) 02.   (+) Lipolysis (7) 03.     (-) Lipogenesis 
03. Liver--(+) Lipolysis (7)    (-) Lipogenesis
04. Skeletal muscle --(+) Fatty acid oxidation.

Symptoms :-
The easiest way to do this if you are heavy is to look in the mirror.  If you’re overweight you definitely are Leptin resistant.
If you still have a large appetite and crave carbohydrates, especially at night, these are also signs that you are likely Leptin resistant. 
If you are fit or in decent shape and not sure based upon the above symptoms.

LAB DIAGONOSIS :-

01. Blood test and check your reverse T3.  It will be elevated.
02. Salivary cortisol level.
03. With LR, you will always see higher cortisol levels later in the day.
04. Blood  Fasting Leptin & Insulin.

MEDICAL TREATMENT :-
01. Byetta and Symlin (Aelopathy)
02. African plant, Irvingia Gabonensis (Herbal)
03. TRIKATU, SHILAJIT, TERMARIC + NEEM.  (Ayurveda).

Leptin and Insulin : -

POTATO PHOTO 


Leptin and insulin signaling have a very close relationship. When insulin increases, so does leptin. It makes sense – you eat a big meal, your insulin levels go up, and then leptin goes up, signaling to the brain that you're full and to keep the metabolism chugging. The insulin producing beta cells in the pancreas also have leptin receptors, where leptin is a negative regulator of insulin release. So there's a tight intertwined relationship between these two hormones.
01. You eat some wild salmon and a big sweet potato. The beta cells in your pancreas produce insulin in response to your blood glucose level.
02. Insulin stimulates leptin production in your fat cells.
03. Leptin levels go up, triggering the hypothalamus to decrease appetite.
04. High levels of leptin also tell your pancreas to stop making insulin.

But here's how it looks when you have leptin resistance :-

01. You eat some wild salmon and a big sweet potato with some pop tarts, as you're in "perma bulk" mode. The beta cells in your pancreas produce insulin in response to your blood glucose level.
02. Insulin stimulates leptin production in your fat cells, overwhelming your body.
03. Leptin levels go up but leptin resistance starts to set in.
04. High levels of leptin try to tell your pancreas to stop making insulin, but you're leptin resistant so the pancreas doesn't get the message to stop.
05. We now have chronically high levels of insulin, leading to insulin resistance. 

Leptin and Your Thyroid :-

01. It's common knowledge among meat heads that when you diet, your thyroid slows down the conversion of T-4 to T-3. What isn't so commonly known is that leptin is a major player in keeping this conversion going.
02. When your brain senses correct levels of leptin, it tells your liver to convert the inactive T-4 to active T-3 (the active version of thyroid hormone). Your liver will stop this when your brain 
perceives starvation, which is exactly what happens when you have leptin resistance.

Discussion and conclusion :-
This difference may reflect the different hormonal environments in men and women. For instance:-
01. Ghrelin seems to be affected by growth hormone release, which differs in men and women.
02.  Leptin seems to influence reproduction and fertility in women, which is related to women’s body fat levels. Women appear to be much more sensitive than men to leptin levels… unless men are given estrogen.
03.  Intranasally administered insulin makes men less hungry and lose weight, but makes women hungrier and gain weight… unless women’s estrogen levels, or men’s testosterone levels, are low.

AFTER TRANSFORMATION

Obesity Management On Diabetes Mellitus TypeII & Insulin Resistance




DIABETES PATHOPHYSIOLOGY & DIAGNOSIS










DIABETES PATHOPHYSIOLOGY & DIAGNOSIS

OVERVIEW
Diabetetes Mellitus is a Chronic disease Of Carbohydrate metabolism characterized by Hyperglycaemia. Hyperglycaemia is the result of insufficient Insulin production and release, resistance to the action of insulin or a combination of both factors. To understand the Strategies for management of Diabetes it is important to understand the relationship between Glucose, Insulin & counter regulatory Hormones and their role in glucose Homoeostasis. 

WHAT IS DIABETES ?
Diabetes mellitus is a group disease characterised by high blood glucose level, disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, or action, or both.
Symptom :-
01. Polyuria - Frequent urination
02. Polydipsia - Feel very thirsty
03. Polyphagia - Feel very hungry
04. General weakness
05. Decreased resistance to infection
06. Decreased ability of wound healing
07. Dehydration as a result of excessive water or electrolyte loss
There may be no symptoms at all.

INVESTIGATIONS :-
01. Fasting Blood Sugar
02. PP Blood Sugar
03. GTT
04. HbA1C
05. Urine sugar

What Causes Diabetes ?
There are two causes leading to Hyperglycaemia and Diabetes :-
01. Insufficient Production of Insulin (Either absolutely/relative to the body’s needs, or
02. The inability of cells to use Insulin properly and efficiently.

Type of DIABETES ?
01. IDDM(Insulin dependent Diabetes mellitus), Type-1
02.NIDDM (Non-Insulin dependent Diabetes mellitus), Type-2
03. MODY (Maturity-onset Diabetes of Young).
04. GDM(Gestational Diabetes Mellitus)

What Causes Insulin Resistance ?
Obesity
01. Pregnancy
02. Infection or Severe illness
03. Stress
04. During Steroid use.

Relationship between Insulin Resistance & Diabetes ?

As mentioned above insulin resistance precedes the development of type-2 diabetes, sometimes by years. In individuals who will ultimately develop type-2 diabetes, it is believed that blood glucose and insulin levels are normal for many years; then at some point, there is often an association of high insulin levels, Central Obesity, Lipid abnormalities, and /or high blood pressure, when this constellation of disease processes occurs, it is known as the metabolic syndrome.

The Metabolic Syndrome:-
01. Raised triglycerides.
02. Raised -Cholesterol.
03. Raised blood pressure.
04. Raised Fasting blood glucose.

Disease of the Exocrine Pancreas
Any condition that injure the pancreas diffusely can result in Diabetes. These condition imply that a mechanism other than simple reduction in beta-cell mass may also be responsible for diabetes.

01. Pancreatitis
02. Trauma or Surgical removal of the pancreas.
03. Cancer of the pancreas.
04. Cystic fibrosis.
05. Fibrocalculous Pancreatopathy.
06. Haemochromatosis, the iron storage disease. 

Diagnostic Criteria of Diabetes :-

Symptoms* of diabetes plus any of the following values :-
01. Random plasma glucose concentration >200mg/dl.
02.Fasting plasma glucose >126 mg/dl.
03. 2 hour plasma glucose >200mg/dl during a 75gm OGTT( oral glucose tolerance test) 
A 75g OGTT is required to confirm the diagnosis in individuals who are asymptomatic but have any one of the above values.

What is Ketones ?
Urine ketones are the result of Fatty acids that breakdown to give the body a form of energy. If the body cannot get energy from glucose, fat is used instead. The by-product of that fatty acid breakdown is KETONES.


What is Diabetes Ketoacidosis ?
DKA occurs when there is a deficiency of INSULIN in the body. This prevents the glucose molecules form entering into cells, hence leading to Hyperglycaemia. The secretion of counter-regulatory hormones such as Glucogon or epinephrine result in release of glucose from the liver, which contributes to increased Hyperglycaemia. This is followed by the Uncontrolled breakdown of Adipose and muscle tissues (CATABOLISM). Fatty acids are released and are rapidly metabolised into  ketones, which are strongly acidic. The excessive production of ketones lower the blood pH and leads to metabolic acidosis.


Signs and Symptoms of DKA :-
01.Thirst and urination (Primary stage).
02. Nausea and vomiting.
03. Abdominal Pain.
04. Legs cramps.
05. Acid smelling breath.
06. Kussmaul’s breathing.

NOTE:- If these symptoms are present, immediately Medical advise &Supervision  is Required.

MANAGEMENT OF DIABETES :-
01. Aware the patient about D.M  
02. Life style Modification.
03. Behavioral Therapy.
04. Nutritional Therapy.
05. Physical exercise therapy.
06. Pharmacological Treatment.
07. Pschycological counseling.
08. Family Counseling & Education.

Weight Gain with Insulin :-

Insulin decrease fat breakdown and increases fat formation. Therefore, weight gain is often associated with commencement or intensification of insulin therapy. Weight gain is related to :-
Absorption of calories that were previously lost  in the urine through glucosuria. When blood glucose levels are elevated, the body will excrete excess glucose through urine. If, once insulin is initiated, the person with diabetes continues to eat as usual, those calories will be absorbed and the person will gain weight.
Insulin tends to stimulate appetite, people will eat more because they are hungry. If the insulin dose is increased to compensate for the increased number of calories, then appetite is stimulated more and the blood glucose raises. This is called “Chasing blood sugar” . This may result in ‘Overinsulinisation’ or taking more insulin than needed.
Note:- Therefore, all the patients commencing  insulin therapy should meet with a Dietitian/Obesity consultant to develop a meal plan that will match the calories eaten to the insulin given.
1-3 unit-rapid acting insulin per 15gm Carbs. (60Kcal= 1-3Unit Insulin)
0.72-2 unite/ 10gm carbs. 

Related Complication with DM :-
01. Hypoglycaemia.
02. Hyperglycaemia.
03. Macrovascular Complication.
04. Diabetic Retinopathy.
05. Diabetic Nephropathy.
06. Diabetic Neuropathy.


AFTER TRANSFORMATION

Friday 29 July 2016

Obesity Management In Hypothyroid Patient

We have so many in-portent gland in our Body like Pituitary Gland, Thyroid Gland, Pancreas, Liver, Kidney, Reproductive Gland Etc. Thyroid is very Much Importent gland In Our  Body the Hormone Secreate From Thyroid Gland Called Thyroxin,which is help for Digestion, Muscular Movement, Mental Health Etc. If by any reson thyroxin Secreate less from the requirement than bellow Symptom will appear in our body. for Weight loss patient Should Do. With proper Obesity management under Experience Clinical Obesity Consultant/or Medical Professional.


Symtom Of Hypothyroid
01. Obesity
02. Skin texture - dull
03. Puffy Face & Bloated Look
04. Feet Swollen
05. Not loosing weight
06. Constipation
07.Tiredness 
08. Decrease Pulse Rate (Bradycardia) Below 60b/min
09. Knee Reflex  (Jerk)++
10.  Depressed
11. Recurrent  Miscarriage
12. Eyes lustreless
13. Infertility
14. Hair-Dull & brittle, Fall
15. Acidity
16. Non-pitting edema
17. Irregular Period 

TEST :- blood for TSH, T3, T4, Free T4.

Normal Level :- 0.5 - 5.0  (Some Dr. Rec 0.3-3.0) (vary Lab wise).

MANAGEMENT

01. Nutrition ( Balance diet, high in Iodine, Fiber, Potacium, Medium Cereal, Medium Protein, Medium Fat Recomended).
02. Physical Activity :- Focus on Cardio Vasculor Exercise Like Brisk Walking, Swimming, Dansaerobics, Aquea Aerobics Atleast 45min-1Hour. Burger Exercise. 
03. Phermacological treatment : Like Eltroxin, Thyronom, Thyrox Etc Suggested Dose By Respective Doctor. Depend on Level & Body Weight of Patient.
04. ATIN'S International Treatment By emphasizing Balance Diet, Physical / Passive Acti Activity With Specific Slimming Treatment.

Thursday 28 July 2016

Infertility And Obesity Management

Women in the study who were severely obese were 43% less likely to achieve pregnancy than normal-weight women or women who were considered overweight but not obese during the yearlong study.
The study is among the first to examine the relationship between body weight and infertility in women who ovulate,  
"We found that obesity is an additional risk factor for infertility in women who have regular [menstrual] cycles,"  . "This is important given the increase in obesity worldwide."
Obesity and Infertility
WORLD WIDE followed 3,029 couples who were having trouble conceiving on their own.
All the couples had spent a year or more trying to conceive, and none had obvious reasons for fertility problems -- the women were ovulating and had at least one functioning fallopian tube, and the men had normal semen analyses.
The couples were followed until pregnancy was achieved or until they started fertility treatments. In addition to a fertility history, the women's weight, height, and smoking status were measured at study entry.
The women were classified as underweight, normal weight, overweight, or obese based on their body mass index (BMI).
The vast majority of the study participants (86%) were either normal weight or overweight.
An additional 10% were obese, with BMIs of 30 or more. These women had the most trouble conceiving during the yearlong observation.
For example, a woman with a BMI of 35 was found to be 26% less likely to achieve a spontaneous pregnancy than women who were normal weight or overweight but not obese.
A woman with a BMI of 40 or more was 43% less likely to get pregnant.
AFTER TRANSFORMATION

BEFORE TRANSFORMATION